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  • Product not yet rated Includes a Live Web Event on 11/07/2023 at 8:00 AM (PST)

    Webinar sponsored by Selux (no CE offered)

    Description: 

    Date: November 7, 2023

    Time: 11:00 am - 12:00 pm ET / 8:00 - 9:00 am PT

    Bloodstream infection is a medical emergency that necessitates promptly administering appropriate antibiotics. The current laboratory procedure for antimicrobial susceptibility testing (AST) involves a subculture of organisms from positive blood bottles, followed by a legacy AST system testing or disk diffusion method. New rapid antimicrobial susceptibility testing (rAST) technologies have been developed in recent years that eliminate the subculture step, preparing the samples directly from positive blood cultures, effectively reducing the time-to-result by several hours to one day. In this sponsored webinar, the presenters will discuss the importance of rAST and the clinical and financial benefits of rAST for blood cultures and septic patients, the necessity to use the current breakpoints to report MIC results, as well as the clinical evaluation results from the Selux Direct Positive Blood Culture AST system.

    Target Audience: 

    Nurses, advanced practice providers, physicians, emergency responders, pharmacists, medical technologists, respiratory therapists, physical/occupational therapists, infection prevention specialists, data/quality specialists, and more.

    Webinar Supporter: 

    Sepsis Alliance gratefully acknowledges the support provided by Selux Diagnostics for this webinar. 

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    James Lewis, PharmD

    Infectious Disease Pharmacist

    Oregon Health and Science University

    James Lewis, PharmD, is the Clinical Supervisor for Infectious Disease at Oregon Health and Science University (OHSU). His responsibilities include co-directing the OHSU antibiotic stewardship program and serving as the infectious diseases clinical pharmacist for OHSU. He is the co-chair of the antibiotic subcommittee of the Clinical Knowledge and Therapeutics Executive Committee (formerly Pharmacy and Therapeutics Committee) and also serves as the PGY-1 &2 ID rotation preceptor. Dr. Lewis’ professional interests are antibiotic susceptibility testing, antibiotic/antifungal utilization, and the optimal integration of rapid microbiology diagnostics in antibiotic stewardship. Dr. Lewis also currently serves as the co-chair of the breakpoint working group of the Clinical and Laboratory Standards Institute and is a member of the editorial board for Antimicrobial Agents and Chemotherapy.

    Thomas Kirn, MD, PhD

    Professor, Department of Pathology and Medicine

    Rutgers Robert Wood Johnson Medical School

    Thomas Kirn, MD, PhD, is a Professor in the Department of Pathology and Medicine at Rutgers Robert Wood Johnson Medical School. His general research interests are in the areas of microbial pathogenesis and molecular techniques for infectious disease diagnostics. Dr. Kirn’s current research studies include investigation of a novel, rapid method for identification of S. aureus in positive blood cultures and elucidation of molecular mechanisms that contribute to C. difficile pathogenesis.

  • Product not yet rated Includes a Live Web Event on 10/26/2023 at 10:00 AM (PDT)

    Delve into the intricacies of sepsis diagnosis, treatment, and care for individuals with limited English proficiency.

    Description: 

    Date: October 26, 2023

    Time: 1:00 - 2:00 pm ET / 10:00 - 11:00 am PT

    As a result of federal funding, Dr. Cindy Hou is the recipient of a grant from the Office of Minority Health and has lectured about sepsis to people whose primary language is Spanish. Along the way, she uncovered that little research has been published about sepsis in persons with limited English proficiency (LEP). In this webinar, delve into the intricacies of sepsis diagnosis, treatment, and care for individuals with LEP. Dr. Hou will overview the federal right of every individual to a medical interpreter, clinical outcomes of individuals with LEP, and will provide a review of studies of sepsis in LEP.

    Learning Objectives: 

    At the end of the activity, the learner should be able to:

    • Restate the federal rights patients have to utilize a medical interpreter;
    • Incorporate the National Standards for Culturally and Linguistically Appropriate Services (CLAS) in Health and Healthcare into the care of patients with sepsis who have limited English proficiency (LEP);   
    • Review case studies of sepsis in patients with LEP.

    Target Audience: 

    Nurses, advanced practice providers, physicians, emergency responders, pharmacists, medical technologists, respiratory therapists, physical/occupational therapists, infection prevention specialists, data/quality specialists, and more.

    Webinar Supporters:

    Sepsis Alliance gratefully acknowledges the support provided for this webinar by the Sepsis Alliance Institute sponsors.

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    Cindy Hou DO, MA, MBA, FACOI, FACP, FIDSA

    Infection Control Officer

    Jefferson Health, New Jersey

    Cindy Hou, DO, MA, MBA, CIC, CPHQ, FACOI, FACP, FIDSA, is the Infection Control Officer and Medical Director of Research for Jefferson Health - New Jersey (JNJ) and an infectious diseases specialist. She is dually board certified in internal medicine and infectious diseases. Dr. Hou has expertise in sepsis, antibiotic stewardship, and infection control. Dr. Hou is the Chief Medical Officer of  Sepsis Alliance and a member of its board of directors; she is also a medical advisor for the Sepsis Innovation Collaborative. Dr. Hou earned an M.B.A. and M.A. from Boston University, a D.O. from the University of New England College of Osteopathic Medicine, and a BS from Yale University. She has a certification in Infection Prevention and Control (CIC), is a Certified Professional in Healthcare Quality (CPHQ), and a Certified Professional in Patient Safety (CPPS). Dr. Hou is a fellow for the American College of Osteopathic Internists (ACOI), American College of Physicians (ACP) and the Infectious Diseases Society of America (IDSA). 

    No relevant financial relationships to disclose.

    Provider approved by the California Board of Registered Nursing, Provider Number CEP17068 for 1.2 contact hours.

    Other healthcare professionals will receive a certificate of attendance for 1.0 contact hour.

    Medical Disclaimer

    The information on or available through this site is intended for educational purposes only. Sepsis Alliance does not represent or guarantee that information on or available through this site is applicable to any specific patient’s care or treatment. The educational content on or available through this site does not constitute medical advice from a physician and is not to be used as a substitute for treatment or advice from a practicing physician or other healthcare professional. Sepsis Alliance recommends users consult their physician or healthcare professional regarding any questions about whether the information on or available through this site might apply to their individual treatment or care.

  • Product not yet rated Includes a Live Web Event on 10/19/2023 at 11:00 AM (PDT)

    Live webinar about the nurse’s role and responsibility in AMR and AMS

    Description: 

    Date: October 19, 2023

    Time: 2:00 - 3:00 pm ET / 11:00 am - 12:00 pm PT

    A multidisciplinary approach is needed to implement an effective antimicrobial stewardship (AMS) program. Traditionally, nurses have been excluded from the AMS team structure. However, to steer a successful program in the increasingly complex field of health care, it is crucial to involve dedicated nurses and nursing professionals. The role of nurses in caring for and improving outcomes for patients with infections and sepsis is well known. Nurses can also directly impact antimicrobial resistance (AMR) and antimicrobial stewardship (AMS) through a variety of nurse-driven protocols and practices. These can include assessments and allergy documentation, evidence-based specimen collection techniques, consideration for antimicrobial duration and route of administration, and thoughtfulness in culturing. In this presentation, attendees will learn about the nurse’s role and responsibility in AMR and AMS, gain an understanding of opportunities for and barriers to nurses’ engagement in AMS across the continuum of care, and examine key strategies to empower nurses’ ownership, accountability, and contribution to the core elements of AMS.

    Target Audience: 

    Nurses, advanced practice providers, physicians, emergency responders, pharmacists, medical technologists, respiratory therapists, physical/occupational therapists, infection prevention specialists, data/quality specialists, and more.

    Webinar Supporter:

    Sepsis Alliance gratefully acknowledges the support provided for this webinar by Roche.

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    May M. Riley, MSN, MPH, RN, ACNP, CCRN, CIC, FAPIC

    Infection Control Consultant

    Stanford Health Care

    May Riley, MSN, MPH, RN,ACNP, CCRN, CIC, FAPIC is an Infection Control Consultant at Stanford Health Care. May has been practicing in the field of infection control and hospital epidemiology since 2005. She has extensive nursing experience including medical/surgical, neurosurgery, trauma, liver transplant, and critical care nursing. May holds two master degrees, an MSN from the UCLA School of Nursing in acute care, and an MPH in Epidemiology from the UCLA School of Public Health. She will start her doctor of nursing practice study in August. 
    May has numerous publications on infection prevention and infectious disease control. May served on the ANA/CDC Work Group for Engaging Nurses in Antibiotic Stewardship as a subject matter expert to contribute her expertise in developing the ANA/CDC White Paper defining the nurse’s role in stewardship. Additionally, May collaborated with APIC to conduct a leadership interview. She interviewed the founders and pioneers in the ANA/CDC Work Group for Engaging Nurses in Antibiotic Stewardship. To trumpet the vision and mission of engaging nurses to antibiotic stewardship, May published the leadership interview article in one of the APIC flagship journals  ̶  Prevention Strategist in 2016. 
    May is also a Consulting Editor for Journal of “Critical Care Nursing Clinics of North America” in Elsevier. 

  • Includes a Live Web Event on 10/10/2023 at 12:00 PM (PDT)

    Live CE webinar regarding the inclusion of the SEP-1 bundle in the Hospital Value-Based Purchasing (VBP) program

    Description: 

    Date: October 10, 2023

    Time: 3:00 - 4:00 pm ET

    The Centers for Medicare and Medicaid Services (CMS) recently finalized the inclusion of the Severe Sepsis and Septic Shock Management Bundle (SEP-1) in the Hospital Value-Based Purchasing (VBP) program as part of the fiscal year 2024 Hospital Inpatient Prospective Payment System (IPPS). SEP-1 has been a part of the Hospital Inpatient Quality Reporting Program since fiscal year 2017. Research on the SEP-1 bundle showed compliance improved outcomes and lowered mortality from 27% to 22%. With the new addition to the VBP program, hospitals are now incentivized to improve sepsis care by not only requiring them to report on their sepsis care but to meet standards for how often they comply. A hospital’s VBP total performance score (TPS) is based on performance, as compared to their peers, and determines whether they receive full payment or not.

    During this webinar attendees will receive an overview of the key components of the SEP-1 measure and the Hospital VBP program. Learners will also delve into the implications of SEP-1 addition to VBP and making it a pay-for-performance measure versus a pay-for-participation measure and what this means for them organizationally. Lastly, strategies on how to analyse and improve organizational SEP-1 compliance and maximize VBP total performance score (TPS) will be discussed.

    Target Audience: 

    Nurses, advanced practice providers, physicians, emergency responders, pharmacists, medical technologists, respiratory therapists, physical/occupational therapists, infection prevention specialists, data/quality specialists, and more.

    Webinar Supporter: 

    Sepsis Alliance gratefully acknowledges the support provided for this webinar by the Sepsis Alliance Institute sponsors.

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    Provider approved by the California Board of Registered Nursing, Provider Number CEP17068 for 1.2 contact hours.

    Other healthcare professionals will receive a certificate of attendance for 1.0 contact hours.

    Medical Disclaimer

    The information on or available through this site is intended for educational purposes only. Sepsis Alliance does not represent or guarantee that information on or available through this site is applicable to any specific patient’s care or treatment. The educational content on or available through this site does not constitute medical advice from a physician and is not to be used as a substitute for treatment or advice from a practicing physician or other healthcare professional. Sepsis Alliance recommends users consult their physician or healthcare professional regarding any questions about whether the information on or available through this site might apply to their individual treatment or care.

  • Recorded On: 08/31/2023

    Content provided by Beckman Coulter (No CE credits offered)

    Webinar Description: 

    In this sponsored webinar, Tobin Efferen, MD, MS, will explore the development of machine learning models in the prediction and diagnosis of sepsis. Dr. Efferen will review some of his own research around the inclusion of biomarkers in AI models and share information on potential future products.

    No CE credits are offered for this sponsored webinar. Content was determined by the sponsor.

    Webinar Sponsor: 

    Sepsis Alliance gratefully acknowledges the support provided by Beckman Coulter for this sponsored webinar.

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    Tobin Efferen, MD, MS

    Medical Director, Medical and Scientific Affairs

    Beckman Coulter

    Tobin Efferen, MD, MS, has practiced emergency medicine on the south and west side of Chicago for the last 15 years. Initially interested in marine biology, Dr. Efferen switched gears after a brief stint at the New England Aquarium in Boston. As a laboratory technician at a biotech startup in Connecticut, he performed both basic and translation biobehavioral research on novel antipsychotic compounds. After receiving a master’s degree in Neurobehavioral Biology from NYU, he continued on to the NYU School of Medicine for his MD. He went on to complete a residency in emergency medicine at the University of Chicago. After graduating he stayed on at Mount Sinai Hospital as an attending, covering both Holy Cross Hospital and Mount Sinai Hospital in the Sinai Health System. As the Assistant Medical Director for the Emergency Department, Dr. Efferen oversaw the quality program and was the Director of the clerkship in emergency medicine for six physician assistant programs in the Chicagoland area.

    He now works part time in the ED and full time as a Medical Director on the Medical/Scientific Affairs team for Beckman Coulter. His work there is focused on the scouting of novel biomarkers to improve the identification and evaluation of complex disease states such as dysregulated host response and acute kidney injury. Another area of focus is the development and implementation of machine learning-based algorithms for use in the emergent and critical care settings.

  • Recorded On: 08/24/2023

    Gain invaluable insights to enhance prehospital practices and ultimately improve patient survival rates and outcomes.

    Description: 

    The profound impact and implications of several recently published papers have reshaped our understanding of prehospital alerts, antibiotics, and fluid administration. Drawing from this cutting-edge research and innovative methodologies, attendees will explore the transformative effects of prehospital alerts on emergency medical services (EMS) and the subsequent improvements in patient outcomes. The intricacies of alerts, clinical decision-making, and resource allocation will be highlighted, in addition to the importance of accurate and timely information in prehospital care. Antibiotic administration in prehospital settings, the latest evidence on fluid administration, and the potential benefits, risks, and controversies of this crucial intervention will also be examined. By synthesizing these recent updates, this presentation aims to equip healthcare professionals with invaluable insights to enhance prehospital practices and ultimately improve patient survival rates and outcomes.  

    Learning Objectives: 

    At the end of the activity, the learner should be able to:

    • Analyze the implications of updates on prehospital alerts, antibiotics, and fluid administration;
    • Evaluate the relationship between prehospital alerts and clinical decision-making;
    • Apply knowledge gained to assess the potential benefits and challenges associated with alerts in EMS;
    • List proposed effective strategies for antibiotic administration and fluid management in prehospital care based on recent research.

    Target Audience: 

    Nurses, advanced practice providers, physicians, emergency responders, pharmacists, medical technologists, respiratory therapists, physical/occupational therapists, infection prevention specialists, data/quality specialists, and more.

    Webinar Supporters:

    Sepsis Alliance gratefully acknowledges the support provided for this webinar by the Sepsis Alliance Institute sponsors.

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    Rommie L. Duckworth, MPA, LP, EFO, FO

    Captain, EMS Coordinator

    Ridgefield (CT) Fire Department

    Rom Duckworth, MPA, LP, EFO, FO, is a dedicated emergency responder, author, and educator with more than thirty years of experience working in career and volunteer fire departments, hospital healthcare systems, and private emergency medical services. Rom is currently a career fire Captain and paramedic EMS Coordinator for Ridgefield (CT) Fire Department and Founder of the New England Center for Rescue and Emergency Medicine. Rom is the recipient of the American Red Cross Hero award, Sepsis Alliance Sepsis Hero award, the EMS 10 Innovators award, and the NAEMT Presidential award. An Advisory Board member for the Sepsis Alliance, Rom is the co-author of the Sepsis Care chapter in the NAEMT Advanced Medical Life Support (AMLS) program as well as chapters in more than a dozen EMS, fire, rescue, and medical textbooks and over 100 published articles in fire and EMS journals, magazines, and websites. Rom is an international advocate and leader in emergency services education.  

    Provider approved by the California Board of Registered Nursing, Provider Number CEP17068 for 1.7 contact hours.

    Other healthcare professionals will receive a certificate of attendance for 1.25 contact hours.

    Medical Disclaimer

    The information on or available through this site is intended for educational purposes only. Sepsis Alliance does not represent or guarantee that information on or available through this site is applicable to any specific patient’s care or treatment. The educational content on or available through this site does not constitute medical advice from a physician and is not to be used as a substitute for treatment or advice from a practicing physician or other healthcare professional. Sepsis Alliance recommends users consult their physician or healthcare professional regarding any questions about whether the information on or available through this site might apply to their individual treatment or care.

  • Recorded On: 07/27/2023

    Recorded peer-to-peer roundtable discussion on innovative approaches, protocols, tools, and documentation practice which have improved sepsis management and care at panelists' organizations.

    Description: 

    In this peer-to-peer roundtable discussion, sepsis coordinators and specialists will discuss the innovative approaches, protocols, tools, and documentation practice which have improved sepsis management and care at their organizations. Our panelists represent a variety of care situations from critical access hospitals to larger academic centers. 
    Panelists will share what has worked at their institutions, ranging from critical access hospitals to larger academic centers, as well as areas where they still struggle and the adjustments, they’ve made to improve outcomes and meet requirements. Topics of discussion will include documentation, promoting buy-in and physician support for a sepsis program, and the evolution of fluid resuscitation. 

    Target Audience: 

    Nurses, advanced practice providers, physicians, emergency responders, pharmacists, medical technologists, respiratory therapists, physical/occupational therapists, infection prevention specialists, data/quality specialists, and more.

    Learning Objectives:

    At the end of this activity, the learner should be able to: 

    • Explain different care situations and challenges faced by sepsis coordinators or healthcare professionals managing sepsis;
    • Summarize the areas where sepsis coordinators and specialists struggle in sepsis management and care, and identify the adjustments made to improve outcomes and meet requirements; 
    • Describe the importance of documentation in sepsis management and care;
    • Analyze the evolution of fluid resuscitation in sepsis management, including its historical context and the current best practices. 

    Webinar Supporters:

    Sepsis Alliance gratefully acknowledges the support provided for this webinar by the Sepsis Alliance Institute sponsors.

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    Michelle Evans, RN, MSN, NP-C

    Sepsis Program Coordinator

    Summa Health System

    Michelle Evans, RN, MSN, NP-C, obtained her associate's degree in nursing in 1999 and her bachelor of science in nursing in 2007, both from Walsh University. She earned her master's in advanced practice nursing in 2010 from Malone University and is board-certified through the ANCC as a family nurse practitioner. Her clinical background is critical care/rapid response and hospitalist medicine. She carried her CCRN Certification through the AACN from 2005 - 2017, and is trained in fundamentals of critical care support through the Society of Critical Care Medicine. Michelle discovered her passion for sepsis care while serving as the Intensivist Program Coordinator for Aultman Hospital from 2002-2009. She is currently employed at Summa Health System as the Sepsis Program Coordinator, a program/role created in January, 2021. Michelle resides in Canton, Ohio, with her husband Dave, and Luke, her youngest of three sons.

    Devang Sanghavi, MD, MHA, FCCP

    Vice Chairman, Clinical Practice and Critical Care

    Mayo Clinic, Jacksonville, FL

    Devang Sanghavi, MD, MHA, FCCP, is Vice Chairman, Clinical Practice and Critical Care and an Associate Professor at Mayo Clinic in Jacksonville, Florida. His educational experience includes board certification in internal medicine from Presence Saint Joseph Hospital in Chicago and Chief Residency in Internal Medicine at Presence Saint Joseph Hospital. He graduated from the Critical Care fellowship training program at Mayo Clinic, Rochester, followed by board certification in Critical Care Medicine. Dr. Sanghavi completed his graduate training at Washington University School of Medicine in Saint Louis, having completed a two-year master's program in Health Administration.

    As a Chief Resident in Chicago, Dr. Sanghavi led a group of eighty-four residents and medical students, which tested his administrative, leadership, and teaching skills. Caring for a critically ill patient with multisystem involvement demands an alert physician, one who is a team player, quick, decisive, and ready to respond to the ever-changing needs of this patient. It is these very demanding conditions and the daily change of medical conditions that one may treat that drew Dr. Sanghavi to critical care.

     

    Alexis Wells, RN, MSN, LSSYB, CCDS

    Quality Educator, Outcomes Management & Quality Division

    JPS Health Network

    Alexis Wells, MSN, RN, LSSYB, CCDS, has been a registered nurse since 2008 working in various areas including CVICU, neuro ICU, med/surg ICU, telemetry, bone marrow transplant unit, and home hospice, which provided a well-rounded foundation when she became a clinical documentation specialist (CDS) in 2015. Within six months, Alexis was promoted as the clinical coordinator at her facility, providing education to providers and cultivating relationships with essential ancillary departments such as dietary, wound care, and IT. In 2018, Alexis was hired at John Peter Smith (JPS) Hospital as the CDI Quality Assurance Auditor, where she continued the same goal to break down barriers and improve workflow and engagement of everyone involved with clinical documentation. In December 2021, Alexis transitioned to a new role at John Peter Smith as the Quality Educator for the entire organization.

    Alexis has taken care of multiple patients with sepsis and understands early identification and intervention is KEY to survival, which is why she took to action again when the question was posed: how do you bridge patient care and reimbursement when it comes to the septic population?

    Jessica Aguilar, BSN, RN, LP, LSSGB

    Sepsis Coordinator

    JPS Health Network

    Jessica Aguilar, BSN, RN is a clinical sepsis nurse at JPS Health Network in Ft. Worth, Texas. As a clinical sepsis nurse, she is responsible for educating patients and staff on sepsis. She is currently completing her Masters in Nursing Administration at Texas Tech University. She began her career as a pharmacy tech, then obtained her EMT and EMT-Paramedic prior to completing her BSN. She previously worked as a bedside nurse at Cook Children’s Medical Center from 2015-2017 and was involved in hardwiring sepsis rollout to all floors. From 2017-2019 Jessica was an emergency department nurse at JPS Health Network and served as the Chair of the Stroke Committee. Additionally, she was a member of the sepsis, AMI, triage, and MCI committees. Outside of work, Jessica enjoys spending time with her daughter, crafting, working out, and gardening.

    Provider approved by the California Board of Registered Nursing, Provider Number CEP17068 for 2.3 contact hours.

    Other healthcare professionals will receive a certificate of attendance for 1.9 contact hours.

    Medical Disclaimer

    The information on or available through this site is intended for educational purposes only. Sepsis Alliance does not represent or guarantee that information on or available through this site is applicable to any specific patient’s care or treatment. The educational content on or available through this site does not constitute medical advice from a physician and is not to be used as a substitute for treatment or advice from a practicing physician or other healthcare professional. Sepsis Alliance recommends users consult their physician or healthcare professional regarding any questions about whether the information on or available through this site might apply to their individual treatment or care.

  • Recorded On: 06/22/2023

    Recorded symposium featuring subject matter experts in precision medicine and sepsis.

    Description: 

    The clinical complexity and heterogeneity following infection and sepsis is a well-recognized challenge to effective patient management. Traditional pathogen-only targeted treatment currently remains the standard of care in diagnosis and treatment. Precision medicine, a concept that has been around for many years, applies host-directed diagnostics and therapeutics to use a person’s own genes or proteins as a potential way to yield more precise diagnoses, predict disease risk before symptoms occur, and design customized treatment plans that maximize safety and efficiency. For the medical community, precision medicine holds a lot of promise and hope for improved, personalized care and outcomes in infectious diseases and sepsis. 

    This Sepsis Alliance Symposium, focused on precision medicine in sepsis care and examining host-directed diagnosis and treatment for infectious diseases and sepsis, will allow learners to better understand the host response and how precision medicine might be applied. Presenters will also review host-based diagnostics across the continuum and explore the role of data and machine learning in host-based diagnostics and therapeutics.

    Learning Objectives: 

    At the end of the activity, the learner should be able to:

    • Identify the immune activation to immune suppression;
    • Review current host-directed diagnostics and phenotyping being researched, translated, and used in infection and sepsis care;
    • List possible approaches to host-directed therapeutics in infection and sepsis care;
    • Describe the role of data and machine learning in precision medicine.

    Target Audience: 

    Nurses, advanced practice providers, physicians, emergency responders, pharmacists, medical technologists, respiratory therapists, physical/occupational therapists, infection prevention specialists, data/quality specialists, and more.

    Session 1: Immunotherapy of Sepsis: The Right Patient at the Right Time with the Right Drug

    Speaker: Richard Hotchkiss, MD

    Description: The evolving nature of sepsis highlights the crucial role of immunotherapy in its management. This session will delve into the transition of sepsis from a hyper-inflammatory phase to a prolonged immunosuppressive phase, shedding light on the underlying mechanisms and implications for patient outcomes. The critical phase in which the majority of sepsis-related deaths occur will be discussed, along with how to prioritize interventions to improve sepsis survival rates. Emerging immune adjuvant therapy options that can enhance patients’ ability to effectively combat invading pathogens, providing potential breakthroughs in sepsis treatment will also be explored. Learners can expect to become equipped with valuable knowledge to identify the right patients, determine optimal timing, and select the appropriate immunotherapy for sepsis management, ultimately improving patient outcomes.

    Session Objectives: At the end of this session, the learner should be able to: 

    • Describe how sepsis can evolve from a hyper-inflammatory phase to a more prolonged immunosuppressive phase; 
    • Identify the phase in which most deaths in sepsis occur; 
    • List emerging immune adjuvant therapy options to boost patients’ ability to contain and eliminate invading pathogens. 

    Session 2: Phenotypes in Pediatric Sepsis and the Importance of Personalized Care

    Speaker: L. Nelson Sanchez-Pinto, MD, MBI, FAMIA

    Description: Pediatric sepsis is a heterogenous disease: not every child with sepsis has the same type of response to infection or presents with the same clinical picture. These differences can make some children more likely to respond to, or be harmed by, specific therapies. Different children may require very different clinical trajectories. In this presentation, learners will review the importance of identifying and studying phenotypes of pediatric sepsis to advance the science of this potentially devastating syndrome, and how to provide more personalized care to the children affected by it.

    Session Objectives: At the end of this session, the learner should be able to: 

    • Restate the importance of phenotypes and personalized care in pediatric sepsis;
    • List some key examples of pediatric sepsis phenotypes described in the literature; 
    • Describe the concepts of predictive and prognostic enrichment and how they relate to phenotypes and personalized care in pediatric sepsis.

    Session 3: Shaping the Future of Sepsis Care: The Role of Phenotyping in Prognosis

    Speaker: Azra Bihorac, MD, MS, FCCM, FASN

    Description: To use precision medicine for providing sepsis patients with the best available care, we need to understand sepsis subclasses and their biological basis. Current phenotypes of acute kidney injury (AKI), however, are not consistent and are classified by different criteria such as timeline or acuity. Confusion can result from the existing efforts to define sepsis subclasses, where researchers may have used different approaches to classification (empirical, hypothesis-based, or agnostic) and may have used interchangeable terms (such as subgroup, sub-phenotype, or endotype) that were not reconciled with terminology from previously published studies. This presentation will discuss current efforts to establish data-driven phenotypes and how these efforts could be converted into clinical impact in the future.

    Session Objectives: At the end of this session, the learner should be able to: 

    • Discuss and analyze the heterogeneous approaches to defining sepsis phenotypes;
    • Examine the challenges of and potential next steps toward making a clinical impact with sepsis phenotypes.

    Session 4: A Sepsis Innovation Collaborative (SIC) Roundtable: Challenges and Opportunities in Precision Sepsis Diagnosis

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    Speakers: Steven Q. Simpson, MD; Tim Sweeney, MD, PhD; Debra M. Foster, BSc; Bobby Reddy Jr., PhD; Vincent Liu, MD, MS

    Description: Sepsis Innovation Collaborative (SIC) is a multi-stakeholder collaborative that brings together academic, clinical, industry, patient advocacy, and other stakeholders. This roundtable with SIC members will dive into the common challenges and unmet needs related to sepsis and the opportunities precision medicine provides for addressing these issues. In this roundtable session, panelists will address the latest research, technological breakthroughs, and emerging trends, offering participants a unique opportunity to learn about the ongoing development of precision medicine strategies in sepsis management. Panelists will also share how SIC is working to improve patient outcomes and enhance sepsis diagnosis and management through precision medicine.

    Session 5: Human Genomics of Infectious Diseases & Sepsis

    Speaker: Samira Asgari, PhD

    Description: Understanding how human genetic diversity translates to phenotypic diversity in the immune system and how this phenotypic diversity affects the clinical outcome of infectious diseases is critical for developing better preventative and therapeutic measures to fight infections and sepsis. These human genetic differences may be the key to understanding the interindividual variability for infectious disease outcomes. This presentation will provide an overview of the outcomes of any infection and sepsis and the complex interplay between host, pathogen, and the environment. Future applications of precision medicine and host genetics to help patients and decrease health inequities will also be discussed.

    Session Objectives: At the end of this session, the learner should be able to:

    • Summarize the spectrum of genetic architectures in diseases;
    • Evaluate methods and approaches used to study human genomics of infectious diseases.

    Session 6: Strategies for Building a Better Approach to Host-Targeted Therapeutics in Sepsis Care

    Speaker: Timothy G. Buchman, Ph.D., M.D., FACS, FCCP, MCCM

    Description: The frustration experienced by the healthcare community when encountering situations where two patients with similar characteristics receive identical treatment, but one survives while the other succumbs to multiple organ system failure, is a common sentiment. This discrepancy in outcomes may potentially be attributed to variations in host-response. Understanding the impact of individual host-response to infection is crucial in advancing our knowledge of sepsis and improving personalized patient care.  

    In this session, host response to infection will be highlighted, along with the dysregulated host responses which characterize sepsis. Lessons and insights learned from the COVID-19 pandemic will be used to provide an in-depth analysis of the current state of host-targeted therapies with steps that can be taken to provide a more personalized approach to sepsis assessment and care.

    Session Objectives: At the end of this session, the learner should be able to: 

    • Describe the host response to infection; 
    • Identify the dysregulated host responses that characterize sepsis;  
    • Describe the current state of host-targeted therapies that are widely used, including a review of the COVID-19 experience; 
    • Recognize the need and promise for personalized assessment and care; 
    • Explain immediate and intermediate “next steps” to improve the approach to personalized assessment and care.

    Session 7: Resuscitation and Management: Knowns, Unknowns, and the Role for Big Data

    Speaker: Andre L. Holder, MD, MS

    Description: Big data and artificial intelligence (AI) have the potential to improve sepsis care in a number of ways. For example, big data can be used to identify patients at risk for sepsis, to develop personalized treatment plans, and to monitor patient outcomes. AI can be used to develop algorithms that can predict sepsis, to identify patients who are not responding to treatment, and to recommend interventions that are most likely to be successful. This presentation will discuss the current state of knowledge on sepsis resuscitation and management, as well as the areas where there is still uncertainty or controversy. The presentation will also discuss the potential role of big data and artificial intelligence (AI) in improving sepsis care.

    Session Objectives: At the end of this session, the learner should be able to:

    • Summarize topics in which the Surviving Sepsis Campaign provides insufficient guidance or management is controversial:  
    • Restate proper fluid resuscitation techniques in patients with heart failure or ESRD; 
    • Overview timing and patient selection for steroids and other immunosuppressants; 
    • Outline pre-clinical” detection of sepsis or its sequelae;  
    • Restate potential approaches in which Artificial Intelligence (AI) can provide guidance in these three areas.  


    Steven Q. Simpson, MD (Moderator)

    Professor of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine

    University of Kansas

    Steven Q. Simpson, MD is Professor of Medicine at the University of Kansas in the Division of Pulmonary, Critical Care, and Sleep Medicine, where he previously served as Division Director, Director of three ICUs, Chair of the Sepsis Team, and Chair of Multidisciplinary Critical Care. He has done research in all areas of severe sepsis from molecular and cellular mechanisms, to translational studies, to quality improvement studies.

    He was a founder, in 2005, of the Midwest Critical Care Collaborative, a multidisciplinary and interprofessional collaborative effort to improve the quality of critical care services throughout the Midwest. In 2007, he initiated the Kansas Sepsis Project, a statewide program to improve severe sepsis care and outcomes throughout the state via continuing education both in sepsis and in quality improvement principles, and via inter-professional collaboration. He is currently heading a BCBS-sponsored sepsis collaborative among Kansas City metro area hospitals and is a contributing faculty member of the ongoing Surviving Sepsis Campaign collaboratives, leading the effort in the Midwest. He is a participant in the 2016 review and update of the Surviving Sepsis Campaign Guidelines.

    Dr. Simpson was the North American co-chair of the International Single Day Point Prevalence Study for Severe Sepsis and Septic Shock (IMPRESS) in the fall of 2013. During his tenure at the University of New Mexico, he contributed to the discovery of a particular form of sepsis, the Hantavirus Pulmonary Syndrome, and published numerous papers on the clinical description, the hemodynamic description, and the approach to supportive care for patients with the syndrome, including extracorporeal hemodynamic and oxygenation support.

    Dr. Simpson received his M.D. degree from the University of Kansas in 1983. He completed residency training in Internal Medicine at KU in 1986 and fellowship training in Pulmonary Diseases at Rush Medical College in 1989. He has been a faculty member at Rush Medical College, the University of New Mexico, and the University of Kansas. He is a regular reviewer for the journals Critical Care Medicine and CHEST, and he reviews on an ad hoc basis for Shock, the Journal of Intensive Care, JAMA, Virology, and Antiviral Therapy. He is the author of over 70 peer reviewed and invited manuscripts, book chapters, and web-based articles and presentations.

    Dr. Simpson was the Third Eli Lilly and Company Distinguished Scholar in Critical Care Medicine, sponsored by the American College of Chest Physicians and the Chest Foundation for his work in reducing geographic disparities for severe sepsis care (the Kansas Sepsis Project). In 2013 he delivered the Roger C. Bone Memorial Lecture at the annual international meeting of the American College of Chest Physicians, describing the Kansas Sepsis Project. Dr. Bone was Dr. Simpson’s early career mentor and was the progenitor of the criteria used throughout the world to recognize severe sepsis.

    No relevant financial relationships to disclose.

    Richard Hotchkiss, MD

    Professor of Anesthesiology, Medicine, Surgery, and Developmental Biology

    Washington University School of Medicine

    Richard Hotchkiss, MD, studied at the University of Virginia where he received both his undergraduate and medical degrees and was inducted into the Phi Beta Kappa and Alpha Omega Alpha Honor Societies. He trained in two specialties, first in Internal Medicine at Emory University School of Medicine (where he was also Chief Resident), and then in Anesthesia at the Massachusetts General Hospital. Dr. Hotchkiss pursued his interest in critical care as a Fellow at the University of Virginia and then as a Senior Fellow in the Respiratory Intensive Care Unit. In 1987, Dr. Hotchkiss moved to the Department of Anesthesiology at Washington University in St. Louis where he has remained, climbing the ranks to Professor in the Departments of Anesthesiology, Medicine, Surgery, and Molecular Biology & Pharmacology. 

    Dr. Hotchkiss has had a long, successful career as an investigator studying the pathophysiology of sepsis. His many contributions are documented in over 200 publications. A seminal observation from his laboratory was the identification of extensive apoptotic death of immune effector cells in patients dying of sepsis. This discovery led to the concept that apoptosis-induced immunosuppression is an important pathogenic mechanism in sepsis, a finding that has changed the paradigm in search of new therapeutic approaches to this major threat to public health. A review article on sepsis by Drs. Hotchkiss and Irene Karl helped define and promulgate this concept and is now the sixth most cited review article in the New England Journal of Medicine in the last decade. 

    Dr. Hotchkiss has been continuously funded by the National Institutes of Health for approximately 20 years and is the recipient of a number of prestigious awards, including the NIH Research Career Development Award (1995) and the NIGMS Merit Award (2003). Additional honors include serving as President of the Shock Society for which he received the Distinguished Service Award of the Society in 2007. Washington University in St. Louis honored him with its Distinguished Investigator Award in 2008. 

    Lazaro Nelson Sanchez-Pinto, MD, MBI

    Assistant Professor of Pediatrics (Critical Care)

    Northwestern University Feinberg School of Medicine

    Nelson Sanchez-Pinto is an Assistant Professor of Pediatrics at Northwestern University Feinberg School of Medicine, biomedical informatics specialist, and clinical data scientist. His clinical and academic interests focus on patients with a host of critical conditions, including sepsis. 

    Azra Bihorac, MD, MS, FCCM, FASN

    Senior Associate Dean for Research

    University of Florida College of Medicine

    Azra Bihorac, MD, MS, FCCM, FASN, is the Senior Associate Dean for Research at the University of Florida College of Medicine. She is the R. Glenn Davis Professor of Medicine, Surgery, Anesthesiology, and Physiology and Functional Genomics; the Lab Director of the Precision and Intelligent Systems in Medicine Research Partnership (PRISMA); and Co-Director of the Intelligent Critical Care Center (IC), a multi-disciplinary center focused on providing sustainable support and leadership for transformative medical AI research, education, and clinical applications to advance patients’ health in critical and acute care medicine.

    Through her research, Dr. Bihorac is addressing an unprecedented opportunity for world-leading ambient, immersive, and AI innovation to transform the diagnosis, monitoring, and treatment for critically and acutely ill patients. Dr. Bihorac’s vision is to develop tools for intelligent human-centered health care that is tailored to a patient’s “personal clinical profile” using digital data. She is a nationally and internationally recognized expert in medical AI, data science, informatics, and translational research. Since 2010, she has had continuous NIH funding and 185 peer-reviewed publications with more than 10,000 citations.

    Dr. Bihorac is currently a PI for multiple NIH-funded programs, including a $23.5 million, multicenter Bridge2AI project called “A Patient-Focused CHoRUS for Equitable AI,” which seeks to develop a 100,000-patient dataset for AI research in critical care along with AI workforce training events and a set of standards for the ethical use of AI in critical care.

    Tim Sweeney, MD, PhD

    Co-Founder and Chief Executive Officer

    Inflammatix

    Tim Sweeney, MD, PhD, helped invent the core Inflammatix technology and is a licensed physician and data scientist. He completed his MD/PhD at Duke University and then spent time training in the general surgery residency program at Stanford University. While training as a surgeon, he became frustrated with the current diagnostic tools for infection. During his residency research years, he completed a postdoc MS in Biomedical Informatics, during which he worked with Dr. Khatri to identify a new way to diagnose infections based on ‘reading’ the immune system. Their work designing custom informatics algorithms for sifting through heterogeneous large datasets led to the core technology on which Inflammatix is based.

    Debra Foster, BSc

    Clinical Consultant

    Spectral Medical

    Debra Foster, BSc, began her professional career as a registered nurse, specializing in the adult critical care area. Shortly thereafter, Debra joined the critical care clinical research team at Toronto General Hospital. While there, Debra was the project lead for a multi-national, multi-center clinical trial, the MEDIC study. The data was used for a successful 510k de novo submission to the FDA for the Endotoxin Activity Assay (EAA). It was the first in vitro disagnostic (IVD) in the field of sepsis. Debra followed the device to its commercial partner, becoming an employee of Spectral Medical. She was appointed Vice President of Clinical Development in 2011. Debra has led many clinical research projects, including the EUPHRATES and TIGRIS clinical trials for a device to treat patients with endotoxemic septic shock. In December 2021, Debra opted for partial retirement and remains a clinical consultant for Spectral Medical.

    Debra has lectured many times to medical professionals on the topics of sepsis and clinical trials for sepsis. She has co-authored more than 50 articles in peer-reviewed journals and lectured for academic and industry audiences. 

    Session Title: Spectral Medical Sponsored Session: What is Endotoxin and Why is it Important?

    Session Day/Time: Wednesday, September 27, 2023, 1:40 - 2:10 PM EST

    Access Session

    Bobby Reddy Jr., PhD

    CEO & Co-Founder

    Prenosis

    Bobby Reddy, Jr., Ph.D., is an engineer turned entrepreneur who has focused on the development and commercialization of precision medicine products for over 14 years. He co-founded Prenosis, Inc. in 2014 and serves as its CEO. In this role, he has raised capital from investors, been awarded numerous research grants, recruited a dynamic and multi-disciplinary team, and executed various strategic partnerships with huge diagnostic companies, hospitals, manufacturers, technology partners, and others. He is passionate about the problem of the deconvoluting heterogeneity of immune system dysregulation and its relevance in sepsis and other diseases. Dr. Reddy received his Ph.D. in electrical engineering from University of Illinois Urbana-Champaign (UIUC) in 2012 with a focus on biotech devices and algorithms.

    Vincent Liu, MD, MS

    Research Scientist

    Kaiser Permanente Division of Research

    Vincent Liu, MD, MS, is a research scientist at the Kaiser Permanente Northern California Division of Research. His work focuses on the intersection of sepsis, acute severe illness, informatics, and health care delivery with a goal of building a learning hospital system. Dr. Liu is board certified in Internal Medicine, Pulmonary Disease, Critical Care Medicine, and Clinical Informatics. He received his undergraduate degree from the University of Pennsylvania and his medical degree from New York University. He completed his residency training at New York University Hospitals (Bellevue) and a chief residency at Memorial Sloan-Kettering Cancer Center. He also completed a pulmonary and critical care medicine fellowship and has masters degrees in Health Services Research and Biomedical Informatics, both from Stanford University. In addition to his clinical practice and research, Dr. Liu is also the Regional Director of Hospital Advanced Analytics at Kaiser Permanente Northern California, a role in which he leads the development, implementation, deployment, and evaluation of real-time EHR-based risk prediction models across Kaiser Permanente’s 21 hospitals.

    Samira Asgari, PhD

    Assistant Professor, Institute for Genomic Health, Department of Genetics and Genomic Sciences

    Icahn School of Medicine at Mount Sinai

    Samira Asgari, Ph.D. was born and raised in Iran. She obtained her Ph.D. in human genomics of infectious disease from École Polytechnique Fédérale de Lausanne (EPFL) in 2012. In 2017, she moved to Boston for her postdoctoral training in human statistical and population genomics at the Brigham and Women’s Hospital. She started her research group at Icahn School of medicine at Mount Sinai in New York City in 2022. Her research focuses on understanding the human genetic basis of infection and immunity. Some of the questions the Dr. Asgari lab asks include:

    - What are the human genetic variants underlying susceptibility and resistance to specific pathogens?

    - What are the molecular mechanisms connecting these variants to cellular functions and immune responses? and

    - How do differences in population history and demography play into susceptibility and resistance to specific pathogens?

    To answer these questions, they use a combination of statistical, functional, and population genomics methods. 

    Timothy G. Buchman PhD, MD, FACS, FCCP, MCCM

    Professor of Surgery, Professor of Anesthesiology, Professor of Biomedical Informatics

    Emory University School of Medicine

    Timothy G. Buchman, PhD, MD, FACS, FCCP, MCCM has four decades of bedside experience caring for septic patients. A general surgeon, intensive care doctor and virologist, he is currently Senior Advisor, IPA to the Division of Research, Innovation, and Ventures (DRIVe), Biomedical Advanced Research and Development Authority (BARDA), Office of Assistant Secretary for Preparedness and Response (ASPR), US Department of Health and Human Services (HHS). Dr. Buchman’s other current roles include Professor of Surgery, Anesthesiology, and Biomedical Informatics at Emory University, where he founded the Emory Critical Care Center. Dr. Buchman is past president of the Shock Society, of the Society for Complex Acute Illness and of the Society of Critical Care Medicine, the latter being the largest organization of critical care professionals in the world. He is Editor-in-Chief of Critical Care Medicine (www.ccmjournal.org) and Critical Care Explorations (www.ccejournal.org). He is a member of the External Faculty of the Santa Fe Institute. He also serves as site director of the military-civilian partnership, Surgical Critical Care Institute (www.sc2i.org).

    No financial relationships to disclose.

    Andre Holder, MD, MSc

    Assistant Professor, Division of Pulmonary Allergy, Critical Care, & Sleep Medicine

    Emory University School of Medicine

    Dr. Holder is an NIH-funded clinician scientist with board certification in emergency medicine, internal medicine and critical care medicine. He is an assistant professor in the Division of Pulmonary, Allergy, Critical Care and Sleep Medicine at Emory University. His primary area of research focus is the appropriate timing and use of interventions to prevent or mitigate syndromes of critical illness (e.g. sepsis) by forecasting the evolution of patient decompensation and organ failure. Through collaborations with colleagues in Emory’s Department of Biomedical Informatics, he creates and tests data-driven, machine learning algorithms to predict clinical decompensation from sepsis. Other areas of research interest include early sepsis resuscitation and hemodynamic monitoring, cardiopulmonary resuscitation, & novel sepsis biomarkers. He is a practicing intensivist in the medical ICU at Grady Memorial Hospital and the medical/surgical ICU at Emory Midtown Hospital, both in Atlanta, GA. 

    Provider approved by the California Board of Registered Nursing, Provider Number CEP17068 for 3.6 contact hours.

    Other healthcare professionals will receive a certificate of attendance for 3.0 contact hours.

    Medical Disclaimer

    The information on or available through this site is intended for educational purposes only. Sepsis Alliance does not represent or guarantee that information on or available through this site is applicable to any specific patient’s care or treatment. The educational content on or available through this site does not constitute medical advice from a physician and is not to be used as a substitute for treatment or advice from a practicing physician or other healthcare professional. Sepsis Alliance recommends users consult their physician or healthcare professional regarding any questions about whether the information on or available through this site might apply to their individual treatment or care.

  • Recorded On: 06/21/2023

    Content provided by bioMérieux (No CE credits offered)

    Webinar Description: 

    Sponsored by bioMérieux.

    Joint Infections, including septic arthritis and prosthetic joint infections, can be difficult to diagnose. A delay in treatment can result in permanent morbidity or even mortality. In this webinar, Stephen Vella, PhD, will discuss the challenges of current diagnostics of joint infections and how a new FDA-cleared syndromic PCR panel can guide the diagnosis and treatment of both septic arthritis and prosthetic joint infections. Dr. Vella will review the considerations for use in current diagnostic algorithms, followed by an overview of recent clinical publications. He will share expert recommendations on using the panel to potentially positively impact patient management.

    No CE credits are offered for this sponsored webinar. Content was determined by the sponsor.

    Webinar Sponsor: 

    Sepsis Alliance gratefully acknowledges the support provided by bioMérieux for this sponsored webinar.

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    Stephen Vella, PhD

    Medical Science Liaison

    bioMérieux

    Stephen Vella, PhD, is located outside of Washington DC. Dr. Vella obtained his PhD in Microbiology from the University of Georgia and his undergraduate degree, also in Microbiology, at Indiana University. Currently, Dr. Vella works as a Medical Science Liaison for bioMérieux, specializing in molecular biology. He serves as the U.S.-lead for Joint Infection and is in a supportive role for the Gastrointestinal Panel.

  • Recorded On: 05/17/2023

    Learn how to recognize and address potential disparities in access to care, treatment, and outcomes for people in labor and delivery with sepsis.

    Description: 

    Sepsis in labor and postpartum is a leading cause of maternal morbidity and mortality. In this special Maternal Sepsis Week program, you'll learn about the epidemiology of obstetric sepsis and how it affects different populations. Early detection and management of sepsis, awareness of inequities and recognizing the increased risk of adverse outcomes in some obstetrical patient populations is vital to improving outcomes. 
    The importance of equity considerations in sepsis care will also be explored, as well as how to recognize and address potential disparities in access to care, treatment, and outcomes for people in labor and delivery with sepsis. 

    Learning Objectives: 

    At the end of the activity, the learner should be able to:

    • Describe the epidemiology of obstetric sepsis and inequities in sepsis care; 
    • Identify clinical and systems-based challenges in the early recognition and management of sepsis; 
    • Recognize potential strategies in identifying and treating patients with sepsis, with an eye on equity. 

    Target Audience: 

    Nurses, advanced practice providers, physicians, emergency responders, pharmacists, medical technologists, respiratory therapists, physical/occupational therapists, infection prevention specialists, data/quality specialists, and more.

    Webinar Supporter: 

    Sepsis Alliance gratefully acknowledges the support provided by the Ohio Hospital Association for this webinar. 

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    Malavika Prabhu, MD

    Maternal-Fetal Medicine (MFM) Specialist and Assistant Professor

    Massachusetts General Hospital / Harvard Medical School

    Malavika Prabhu, MD, is a maternal-fetal medicine (MFM) specialist and an assistant professor at Massachusetts General Hospital/Harvard Medical School in Boston, Massachusetts. Dr. Prabhu completed her obstetrics/gynecology residency at the University of Washington in Seattle, followed by her MFM fellowship at Massachusetts General Hospital. Her clinical interests include maternal sepsis, infectious diseases in obstetrics, and severe maternal mortality and morbidity. 

    Provider approved by the California Board of Registered Nursing, Provider Number CEP17068 for 1.8 contact hours.

    Other healthcare professionals will receive a certificate of attendance for 1.5 contact hours.

    Medical Disclaimer

    The information on or available through this site is intended for educational purposes only. Sepsis Alliance does not represent or guarantee that information on or available through this site is applicable to any specific patient’s care or treatment. The educational content on or available through this site does not constitute medical advice from a physician and is not to be used as a substitute for treatment or advice from a practicing physician or other healthcare professional. Sepsis Alliance recommends users consult their physician or healthcare professional regarding any questions about whether the information on or available through this site might apply to their individual treatment or care.