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Sepsis remains a leading cause of death in U.S. hospitals and delayed or missed diagnosis continues to drive poor outcomes. Mortality increases by 4–9% for every hour treatment is delayed, yet missed infections, most commonly those that progress to sepsis, remain a leading source of diagnostic error. Rapid recognition and timely treatment can save up to 80% of patients with septic shock.

Advances in molecular diagnostics, host-response biomarkers, and AI-enabled decision support offer new opportunities to improve early sepsis recognition. Diagnostic stewardship, which includes ensuring appropriate test selection, interpretation, and action, is an essential but underutilized strategy to maximize the impact of these innovations.

Below, find a toolkit of resources intended to help clinicians better diagnose sepsis.

Point-of-Care Best Practices Guide

Download this point-of-care resource which summarizes best practices in diagnostic stewardship. 

Download the Guide

Sepsis Diagnostics Educational Courses

Peer-Provided Downloadable Resources

Find downloadable resources submitted by your peers in the Sepsis Alliance Institute Community Library. 

Note that you must be logged in to access the library.

Visit the Sepsis DIagnosis Resource Library

Visit the Technology Resource Library

Patient Education Resources

Visit Sepsis.org to find a variety of patient education resources for those who have been diagnosed with sepsis. 

Visit Sepsis.org

 Sepsis Alliance gratefully acknowledges Beckman Coulter for their support of this Sepsis Diagnostics and Diagnostic Stewardship toolkit.

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