Opening Remarks and Keynote: "Blood Poison": Lessons from Sepsis History

Opening Remarks and Keynote: "Blood Poison": Lessons from Sepsis History

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Description:

This session was part of Sepsis Alliance Summit 2026

During these opening remarks, Sepsis Alliance will introduce this year’s 2026 Erin Kay Flatley Spirit Award Winner. Attendees will hear remarks from both Dr. Carl Flatley, the founder of Sepsis Alliance, and our 2026 award recipient. The Erin Kay Flatley Spirit Award recognizes outstanding dedication, sacrifice, and contribution to improving sepsis awareness and reducing the suffering caused by sepsis. The award was named for Dr. Flatley’s daughter, Erin, who died from sepsis in 2002.

Following Opening Remarks, this keynote, Lessons from Sepsis History, will trace the evolution of sepsis from antiquity to modern medicine, exploring how historical concepts have shaped current understanding and care. Participants will examine sepsis as a complex syndrome influenced by uncertainty, quality improvement movements, and modern approaches to recognition and treatment. The session will also highlight key drivers of today’s sepsis burden, including antimicrobial resistance, health inequities, and healthcare system challenges.

Lesson Objectives:

At the end of this session, the learner should be able to:

  • Appreciate how the early historical framing of sepsis as “blood poisoning,” and subsequent definitional paradigms, have shaped, and at times constrained, our current understanding of the syndrome;
  • Recognize sepsis as a problem of complexity and identify key drivers of sepsis incidence and mortality, such as antimicrobial resistance, systemic faultlines within healthcare, and social determinants of health;
  • Connect current paradigms of prevention, early recognition, and structured care with the broader quality improvement efforts of the twenty-first century.

Target Audience:

Nurses, advanced practice providers, physicians, emergency responders, pharmacists, medical technologists, respiratory therapists, physical/occupational therapists, infection prevention specialists, data/quality specialists, and more.

Carl Flatley, DDS, MSD

Carl Flatley, DDS, MSD

Founder

Sepsis Alliance

On April 30, 2002, Carl Flatley’s life changed. It was the day his daughter, Erin, died from septic shock, something Carl Flatley, DDS, MSD, a retired endodontist, had never heard of. After Erin’s death, Dr. Flatley learned everything he could about sepsis, and was astounded by what he – and millions of other Americans – didn’t know about the condition. He was shocked to learn that, at the time, sepsis killed well over 200,000 people in the U.S. every year and even survivors were often left with serious after-effects. In 2004, Dr. Flatley founded the American Sepsis Alliance, which became Sepsis Alliance in 2007. It became his mission to make sepsis as well-known as cancer, diabetes, and other illnesses. His catchphrase became “So More Survive,” encapsulating his commitment to seeing fewer lives and limbs lost to sepsis.  This unending devotion to Erin’s memory has had a significant impact on many people.

Shelby Hoffman, CRAT, LNA

Shelby Hoffman, CRAT, LNA

Shelby Hoffman, CRAT, LNA, Sunshine Award Winner, has always been described as someone with a big heart. Her passion for caring for other people and animals started at a young age. Riding horses since she was 6 years old helped build a strong foundation of inner strength, courage and natural empathy. When she was 16, her dad was diagnosed with cancer, underwent a lobectomy, and began intense chemotherapy. She was by his side throughout all these life events, which started her on the path to healthcare. She originally went to school for a degree in equine science, then changed paths to become a Health Unit Coordinator (HUC) to better understand how things worked in a hospital before pursuing a different degree. That later led to her becoming a Licensed Nursing Assistant (LNA).

While working on cardiac floors in many different hospitals, she was gradually taught how to read and interpret heart rhythms, officially making the jump to being a monitor tech in 2020 and becoming a Certified Rhythm Analysis Technician (CRAT) in 2026, and is currently working toward her BS in Healthcare Innovation at Arizona State University. Her dad passed when she was 21 of septic shock, which fueled her passion for sepsis awareness and increased her dedication to patient safety.

Today as her 30th birthday approaches, she still rides, owns, and shows horses, having recently won awards at the 2026 Scottsdale Arabian Horse Show with her horse Kaneki. His name came from the nerdier things she enjoys, like gaming, anime, manga, and collecting Pokémon cards.

Parsa Shahinpoor, MD

Parsa Shahinpoor, MD

Hospitalist and Quality Improvement Leader

Northwest Permanente PC

Parsa Shahinpoor, MD, is a frontline hospitalist, teaching physician, and quality improvement leader at Kaiser Permanente Northwest, where he has spent nearly two decades advancing sepsis care–, a role that has connected him with experts around the world. He completed his medical training at the University of New Mexico Health Sciences Center, where he served as an assistant professor of medicine and directed the internal medicine medical student clerkship. He is the author of Blood Poison: The Untold Story of Sepsis (Amplify Publishing, July 2026), available at BloodPoison.com. Blending science, history, and narrative, he writes to make one of medicine's most urgent challenges vivid and accessible, bringing to life the patients and families whose stories illuminate the human cost of sepsis. Outside of medicine, Dr. Shahinpoor is passionate about playing and composing classical and modern piano. He also enjoys mountaineering, windsurfing, and stand-up paddleboarding in the Pacific Northwest.

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