Dr. Nguyen's multiple research interests are medical mycology research, including projects on the mechanisms and clinical impact of antifungal drug resistance, and molecular pathogenesis of invasive Candida infections. Since 2016, she extended her interest in Mucorales genetics and epidemiology. In addition, her research focuses on antibiotic resistant (AMR) bacterial infections and antimicrobial stewardship research, including projects on evolution of tolerance/resistance and pathogenic mechanisms of carbapenem-resistant Enterobacteriaceae (CRE) and other Gram negative bacteria; the development of novel antibiotic treatment strategies based upon bacterial genetics and pharmacokinetic-pharmacodynamic (PK-PD) principles; the clinical and economic impact of AMR infections and antimicrobial stewardship interventions; and clinical trials of new antimicrobials and diagnostic tests. Dr. Nguyen's Transplant Infectious Diseases (TID) research includes projects on the role of the microbiome in infections and outcomes among transplant recipients, the impact of rectal CRE carriage on transplant patients' outcome, and clinical studies and trials on a wide range of opportunistic fungal, bacterial, and viral infections.  She has published numerous papers on the optimal use of rapid, non-culture tests in diagnosing sepsis and other acute infections, and in antimicrobial stewardship interventions.